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Hypoglycaemic activity of Anthocleista vogelii (Planch) aqueous extract in rodents
Author(s) -
Abuh F. Y.,
Wambebe C.,
Rai P. P.,
Sokomba E. N.
Publication year - 1990
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650040106
Subject(s) - chlorpropamide , oral administration , alloxan , pharmacology , aqueous extract , traditional medicine , medicine , aqueous solution , chemistry , diabetes mellitus , endocrinology
The hypoglycaemic effect of Anthocleista vogelii was studied in mice, rats and rabbits. Aqueous extract of the plant obtained by infusion from finely pulverized root was used. The extract (100, 400 and 800 mg/kg) induced significant hypoglycaemic activity in a dose‐related fashion at 2 h after oral administration in mice and rats with ED 25 of 250 mg/kg and 350 mg/kg respectively. The extract (800 mg/kg, orally) similarly induced statistically significant lowering of blood glucose levels at 8 h in normoglycaemic rabbits. The extract (400 mg/kg and 800 mg/kg, orally) also caused reduction of blood glucose levels in alloxan‐induced diabetic animals. The results of this study indicate that the aqueous extract of the roots of Anthocleista vogelii possess favourable hypoglycaemic activity both in normo and hyperglycaemic animals compared to chlorpropamide as a standard.