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Zizyphus sativa fruits: Evaluation of some biological activities and toxicity
Author(s) -
Shah Arif H.,
AiBekairi Abdullah M.,
Qureshi Shoeb,
Ageel Abdulrehman M.
Publication year - 1989
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650030603
Subject(s) - antipyretic , analgesic , acute toxicity , carrageenan , toxicity , pharmacognosy , traditional medicine , bronchodilator , ed50 , biology , biological activity , medicine , pharmacology , in vitro , biochemistry , asthma
The ethanolic extract of Zizyphus sativa Gaertn (Syn. = Z. jujuba Mill.) fruit has been screened for anti‐inflammatory, analgesic, antipyretic, bronchodilator and antimicrobial activities. It has been found to produce significant inhibition of carrageenan‐induced paw oedema and cotton pellet‐induced granuloma pouch and a significant analgesic activity. It did not produce any significant effect on body temperature and isolated guinea pig tracheal chain. It inhibited the growth of Bacillus subtills. During acute toxiciry, test observations were made for 24 h while the animals were treated for 3 months in chronic treatment. External morphological changes, visceral toxiciry, haematological changes, spermatogenic dysfunction, besides effects on average body weight and vital organ weight were recorded. This crude drug was found to be devoid of any significant toxic effects.