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Antimalarial activity of Tiliacora triandra diels against Plasmodium falciparum in vitro
Author(s) -
Pavanand Katchrinnee,
Webster H. Kyle,
Yongvanitchit Kosol,
Dechatiwongse Thaweephol
Publication year - 1989
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650030514
Subject(s) - plasmodium falciparum , alkaloid , isoquinoline , in vitro , chemistry , traditional medicine , pharmacognosy , stereochemistry , biological activity , biology , biochemistry , medicine , malaria , immunology
Abstract Preparations from the roots of the Thai medicinal plant, Tiliacora triandra Diels, were found to have antimalarial activity against Plasmodium fakiparum in vitro. Methanol extraction yielded two alkaloidal components (water‐soluble and water‐insoluble). Only the water‐insoluble alkaloidal component showed an increase in antimalarial activity. From this component, five different alkaloids of the bisbenzyl‐isoquinoline group were isolated and identified as tiliacorine, tiliacorinine, nor‐tiliacorinine A, and two uncharacterized alkaloids G and H. Alkaloid G was found to be the most active in vitro schizontocide (ID 50 , 344 ng/mL) followed by nor‐tiliacorinine A and tiliacorine (ID 50 , 558 and 675 ng/mL, respectively).