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Effect of some hypoglycemic glycans on glucose uptake and glucose metabolism by inverted intestinal fragments
Author(s) -
Perl Meir,
Hikino Hiroshi
Publication year - 1989
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650030511
Subject(s) - carbohydrate metabolism , in vivo , incubation , chemistry , polysaccharide , metabolism , endocrinology , medicine , glucose uptake , carbohydrate , in vitro , glycan , biochemistry , biology , insulin , microbiology and biotechnology , glycoprotein
Polysaccharides which lowered blood glucose concentration in vivo , were examined for their effects on glucose uptake and glucose oxidation by inverted intestinal fragments of rats. The examined polysaccharides exhibited dose‐dependent stimulations of glucose oxidation (CO 2 release) between 75 and 300 μg/ml incubation mixture. The effects increased to maximal values, as compared to the control at external glucose concentrations of 0.06‐0.25 mM (depending on the glycan), after which inhibitory trends were observed. No effect on the rate of glucose uptake could be observed.