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Comparative examination of two Zanthoxylum benzophenanthridine alkaloids for effects in rabbits
Author(s) -
AddaeMensah Ivan,
Munenge Rahab,
Guantai Anastasia N.
Publication year - 1989
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650030502
Subject(s) - zanthoxylum , chloride , chemistry , traditional medicine , medicine , organic chemistry
Cardiovascular activities of nitidine chloride from Zanthoxylum chalybeum have been compared with those of 9‐methoxychelerythrine. Whereas nitidine chloride was found to show significant hypotensive activity in rabbits, 9‐methoxychelerythrine chloride showed no hypotensive activity. The effect of nitidine chloride on isolated rabbit heart was also compared with those of adrenaline and acetyicholine. 9‐Methoxychelerythrine, which has hitherto been regarded as an artefact formed by recrystallization of chelerythrine base from methanol, has been shown in this work to be a true natural constituent of Zanthoxylum chalybeum .