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Studies on the effects of Pluchea indica less root extract on gastroduodenal ulcer models in rats and guineapigs
Author(s) -
Pal Siddhartha,
Chaudhuri A. K. Nag
Publication year - 1989
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650030410
Subject(s) - traditional medicine , acetic acid , medicine , pharmacognosy , phytotherapy , gastric acid , lesion , stomach , pharmacology , chemistry , gastroenterology , biological activity , in vitro , biochemistry , pathology , alternative medicine
The methanolic fraction of P. indica root extract was found to possess significant antiulcer activity in different experimental animal models. In preventive antiulcer tests, significant protective actions in acetylsalicylic acid, serotonin and indomethacin‐induced gastric lesions were observed in experimental rats. The extract also afforded significant protection to chemically‐induced duodenal lesion in guineapigs. Significant enhancement of healing process in acetic acid‐induced chronic gastric lesions were also observed in the extract‐treated animals.