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Effect of tormentic acid on insulin secretion in isolated rat islets of langerhans
Author(s) -
Ivorra M. D.,
Paya M.,
Villar A.
Publication year - 1989
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650030407
Subject(s) - glibenclamide , sulfonylurea , insulin , endocrinology , medicine , secretion , in vitro , islet , chemistry , diabetes mellitus , biology , biochemistry
Tonnentic acid was isolated as the hypoglycemic agent of Poterium ancistroides Desf. The present study reports effects of this compound on isolated islets of Langerhans. We demonstrate that tormentic acid in the presence of 1.66 mM glucose initiates insulin secretion by isolated rat islets of Langerhans in a dose‐dependent fashion at concentrations ranging from 0.05 to 0.5 mM. However, the compound has no effect on the insulin‐releasing capacity of 16.6 mM glucose. Similar results were obtained with the sulfonylurea glibenclamide (0.01 mM) used as a reference. These results suggest that the hypoglycemic effect of tormentic acid is due to a diect effect of the compound in vitro .