Effect of alismol isolated from Alismatis Rhizoma on working heart perfusion in rat | Zendy

Yamahara Johji | Zendy; Matsuda Hisashi | Zendy; Kobayashi Goro | Zendy; Katayama Taiichi | Zendy; Fujimura Hajime | Zendy

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Effect of alismol isolated from Alismatis Rhizoma on working heart perfusion in rat

Author(s) -

Yamahara Johji,

Matsuda Hisashi,

Kobayashi Goro,

Katayama Taiichi,

Fujimura Hajime

Publication year - 1989

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2650030209

Subject(s) - perfusion , heart rate , medicine , traditional medicine , cardiology , drug , pharmacology , blood pressure

The effect of alismol (Oshima et al. , 1983), a sesquiterpenoid isolated from Alismatis Rhizoma which is used as a Chinese crude drug, was studied on rat isolated heart using the working heart perfusion technique. Alismol decreased cardiac output, heart rate and left ventricular pressure, but it increased coronary flow. The drug has been used for the prevention of anginal attacks and our results provide a pharmacological basis for one of the traditional medicinal effects of Alismatis Rhizoma.

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