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Effect of alismol isolated from Alismatis Rhizoma on working heart perfusion in rat
Author(s) -
Yamahara Johji,
Matsuda Hisashi,
Kobayashi Goro,
Katayama Taiichi,
Fujimura Hajime
Publication year - 1989
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650030209
Subject(s) - perfusion , heart rate , medicine , traditional medicine , cardiology , drug , pharmacology , blood pressure
The effect of alismol (Oshima et al. , 1983), a sesquiterpenoid isolated from Alismatis Rhizoma which is used as a Chinese crude drug, was studied on rat isolated heart using the working heart perfusion technique. Alismol decreased cardiac output, heart rate and left ventricular pressure, but it increased coronary flow. The drug has been used for the prevention of anginal attacks and our results provide a pharmacological basis for one of the traditional medicinal effects of Alismatis Rhizoma.