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Active components of ginger exhibiting anti‐serotonergic action
Author(s) -
Yamahara Johji,
Rong Huang Qi,
Iwamoto Masatsugu,
Kobayashi Goro,
Matsuda Hisashi,
Fujimura Hajime
Publication year - 1989
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650030208
Subject(s) - serotonergic , serotonin , ileum , acetone , chemistry , pharmacology , traditional medicine , column chromatography , guinea pig , biological activity , chromatography , biology , medicine , biochemistry , endocrinology , in vitro , receptor
The pharmacological effects of crude drugs and other plant extracts on the contractile responses to serotonin (5‐HT) in isolated guinea pig ileum were examined. The acetone extract of giner was found to possess an anti‐serotonergic effect. The extract was further fractionated by column chromatography and results showed that [6]‐, [8]‐ and [10]‐gingerol were the active components exhibiting anti‐5‐HT action.