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The effect of alismol isolated from alismatis rhizoma on experimental hypertensive models in rats
Author(s) -
Yamahara Johji,
Kobayashi Goro,
Iwamoto Masatsugu,
Matsuda Hisashi,
Fujimura Hajime
Publication year - 1989
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650030205
Subject(s) - rhizome , aldosterone , renin–angiotensin system , plasma renin activity , pharmacology , angiotensin converting enzyme , pharmacognosy , kidney , traditional medicine , medicine , chemistry , endocrinology , biological activity , biochemistry , in vitro , blood pressure
Abstract The antihypertensive action of alismol, a sesquiterpenoid isolated from Alismatis Rhizoma, the rhizome of Alisma orientale Juzepczuk (Alismataceae), was examined in various experimental hypertensive models in rats and the effect of alismol on the activation of plasma renin, angiotensin‐converting enzyme (ACE) and the level of aldosterone were examined in 2‐kidney, 1‐clip hypertensive model. Alismol caused a sustained, though weak, antihypertensive action in all the experimental models, but did not significantly affect the plasma renin activity, ACE activity and the level of aldosterone.