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Prevention of liver damage by aged garlic extract and its components in mice
Author(s) -
Nakagawat Shizutoshi,
Kasuga Shigeo,
Matsuura Hiromichi
Publication year - 1989
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650030203
Subject(s) - hepatotoxin , carbon tetrachloride , cysteine , pharmacology , phytotherapy , hepatitis , liver damage , medicine , liver enzyme , traditional medicine , ccl4 , enzyme , chemistry , toxicology , biology , biochemistry , immunology , toxicity , pathology , alternative medicine , organic chemistry
The hepato‐protective effects of aged garlic extract (GE), S‐allyl cysteine (SAC) and S‐allylmercapto cysteine (SAMC) were evaluated, using mice with acute hepatitis, induced by hepatotoxins. These substances reduced the rise of serum enzyme levels and liver necrosis caused by paracetamol or carbon tetrachloride. It was found that the protective effect of SAMC upon the liver cells were far superior than that of SAC and the other chemicals tested.