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Effects of Thymus species extracts on rat duodenum isolated smooth muscle contraction
Author(s) -
Blázquez M. A.,
ZafraPolo M. C.,
Villar A.
Publication year - 1989
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650030112
Subject(s) - duodenum , acetylcholine , smooth muscle , contraction (grammar) , incubation , pharmacognosy , chemistry , ileum , muscle contraction , pharmacology , dose dependence , traditional medicine , biological activity , biology , in vitro , biochemistry , endocrinology , medicine
The diethylether, ethylacetate and butanolic extracts from Thymus webbianus and Thymus leptophyllus were tested for spasmolytic activity. Pre‐incubation of the isolated rat duodenum with these extracts for 10 min produced a concentration‐dependent inhibition of acetylcholine‐induced contractions. This effect was at least ten times greater with the apolar extracts than with the polar extracts.