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The effects of Mikania cordata (Burm) B. L. Robins. Root extract on gastro‐duodenal ulcer models in rats and guinea pigs
Author(s) -
Pal Siddhartha,
Bhattacharya Siddhartha,
Chaudhuri A. K. Nag
Publication year - 1988
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650020406
Subject(s) - traditional medicine , phytotherapy , gastro , acetic acid , medicine , pharmacognosy , duodenal ulcer , guinea pig , folk medicine , chemistry , pharmacology , gastroenterology , biological activity , biochemistry , pathology , in vitro , alternative medicine , disease , reflux
The methanolic fraction of the root extract M. cordata was found to possess significant anti‐ulcer activity in different experimental models. In preventive tests the extract demonstrated significant protective action in gastric lesions induced by acetylsalicylic acid, serotonin and indomethacin in experimental rats. Significant protection was observed with the extract in chemically‐induced duodenal lesions. Significant enhancement of the healing process was also found to occur in acetic acid‐induced chronic gastric lesions in experimental animals.