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Hypotensive activity of Thymus orospedanus alcoholic extract
Author(s) -
Jimenez J.,
Zarzuelo A.,
Crespo M. E.
Publication year - 1988
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650020311
Subject(s) - vas deferens , in vivo , antagonism , epinephrine , in vitro , pharmacology , blood pressure , ethanol , chemistry , medicine , biology , biochemistry , receptor , microbiology and biotechnology
The hypotensive effects of the alcoholic extract of Thymus orospedanus were investigated in both in vivo and in vitro assays. Our results indicate that the extract reduced rat blood pressure and modified the dose–response curve to epinephrine in the rat vas deferens and the rabbit artery, indicative of a competitive antagonism.