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Ulceroprotective activity of the flavonoids of Genista rumelica Vel
Author(s) -
Rainova L.,
Nakov N.,
Bogdanova S.,
Minkov E.,
StanevaStoytcheva D.
Publication year - 1988
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650020307
Subject(s) - flavonoid , antacid , chemistry , traditional medicine , glycoside , biological activity , pharmacology , stereochemistry , medicine , biochemistry , in vitro , antioxidant
Ulceroprotective action of several flavonoid compounds isolated from Genista rumelica Vel. (total flavonoid mixture, luteoline‐7‐glycoside, genistine) was established on five models of gastric ulcer in rats, genistine being the most active. Comparison was made against several standard antiulcer durgs (Succus Liquiritiae, Caved S, Almagel). A combined drug Flavogastrol, containing total flavonoid mixture, Semmen Lini gel and antacid compounds, was prepared and demonstrated ulceroprotective activity and low toxicity.