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Evaluation of pharmacological activity of a crude hydroalcoholic extract from Jatropha elliptica
Author(s) -
Trebien Herbert A.,
Neves Paulo C. A.,
Yunes Rosendo A.,
Calixto João B.
Publication year - 1988
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650020303
Subject(s) - pharmacology , bradykinin , histamine , serotonin , ileum , chemistry , acetylcholine , in vivo , biology , biochemistry , receptor , microbiology and biotechnology
The pharmacological effect of the hydroalcoholic extract of Jatropha elliptica was analysed in in vivo and in vitro models. When given orally in mice, the extract showed a low acute toxicity (LD 50 5 g/kg). In a dose of 0.5 or 1 g/kg p.o. the extract did not interfere with diuresis in the rat, but was found to be effective in blocking rat paw oedema induced by carrageenan and partially, serotonin‐induced oedema. In the same dose, the extract failed to inhibit rat paw oedema induced by dextran and the increase of rat cutaneous vascular permeability caused by Bothrops Jararaca venom, dextran, histamine, PAF‐acether and serotonin. Pre‐incubation of the isolated rat uterus and guinea‐pig ileum with the extract (0.2–0.8 mg/mL), produced a concentration‐related and non‐competitive inhibition of contractions induced by acetylcholine and bradykinin. However, the extract was about 2‐fold more potent in inhibiting the contraction of both agonists in guinea‐pig ileum than in rat uterine muscle. In rat aorta, the extract (50–100 μg/mL) caused a concentration‐dependent inhibition of noradrenaline‐evoked contractions, being about 5‐fold more potent when compared to the IC 50 values obtained in rat uterus.