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Molluscicidal activities of Dysoxylum lenticellare gillespie constituents on Biomphalaria glabrata say
Author(s) -
Adewunmi C. O.,
Aladesanmi A. J.
Publication year - 1988
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650020211
Subject(s) - biomphalaria glabrata , molluscicide , alkaloid , pharmacognosy , biology , stereochemistry , traditional medicine , botany , biological activity , chemistry , snail , medicine , ecology , zoology , in vitro , biochemistry , schistosomiasis , schistosoma mansoni , helminths
Four alkaloids, dyshomerythrine (2), 3‐epischelhammericine (6), 2,7‐dihydrohomoerysotrine (7); and 3‐epi‐12‐hydroxyschelhammericine (8); two 1‐phenylethylisoquinoline, homolaudanosine (9) and dysoxyline (10); a novel alkaloid, dysazecine (3); two diterpenes, 8β‐hydroxysandaracopimar‐15‐ene (1) and phyllocladene (5) and p ‐hydroxyacetophenone (4) isolated from the leaves of Dysoxylum lenticellare have been tested against Biomphalaria glabrata and found to possess molluscicidal activity. p ‐hydroxyacetophenone (4) demonstrated high molluscicidal activity. An increase in the methoxy groupings increased the activity of the alkaloids whilst the disruption of the carbon skeleton decreased activity. All the compounds tested possessed cardiodepressant activities on the heart of B. glabrata .