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Effect of short‐term administration of cocaine on select organs and the hemopoietic system of B6C3F1 mice
Author(s) -
Valentine J. L.,
Paulsen Robert,
Faith Robert,
MillerHardy Dianne,
Stephen P. M.
Publication year - 1988
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650020210
Subject(s) - vacuolization , mean corpuscular volume , hematocrit , saline , spleen , endocrinology , hemoglobin , ratón , medicine , haematopoiesis , body weight , toxicity , chemistry , biology , stem cell , genetics
Cocaine was administered to B6C3F1 female mice at doses of 10, 20, 30, 40, 50 and 60 mg/kg for 7 consecutive days. Body weight of the cocaine treated animals compared to saline controls demonstrated dose related decreases that were significant at higher doses. Comparison of relative organ weights demonstrated significant increases in liver weight at all dose levels whereas thymus and spleen weight decreased significantly at higher doses. No significant changes were found in adrenal weights. Pathological changes were consistently noted in livers with doses of 30 mg/kg or greater using light microscopy. Electron microscopy studies performed on animals receiving 50 and 60 mg/kg showed hepatocytes in various stages of degenerative vacuolization, which were restricted to centrilobular areas of livers. Numbers of hepatocytes with such changes were dose related. Significant changes in the hemopoietic system were noted at doses of 50 mg/kg for hematocrit, 60 mg/kg for RBCs, 50 and 60 mg/kg for mean corpuscular volume, 40, 50 and 60 mg/kg for hemoglobin, and dose independent changes for the ratio of segmented neutrophils to lymphocytes.