Mast cell stabilizing effect of glucan A and phosphatidyllycorine isolated from  Crinum latifolium | Zendy

Ghosal Shibnath | Zendy; Shanthy Amirthalingam | Zendy; Das Prasun K. | Zendy; Mukhopadhyay Mita | Zendy; Sarkar Mihir K. | Zendy

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Mast cell stabilizing effect of glucan A and phosphatidyllycorine isolated from Crinum latifolium

Author(s) -

Ghosal Shibnath,

Shanthy Amirthalingam,

Das Prasun K.,

Mukhopadhyay Mita,

Sarkar Mihir K.

Publication year - 1988

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2650020206

Subject(s) - degranulation , amaryllidaceae , mast cell , in vivo , traditional medicine , pharmacognosy , in vitro , glucan , pharmacology , biology , chemistry , medicine , immunology , biological activity , biochemistry , botany , receptor , microbiology and biotechnology

The effect of glucan A and phosphatidyllycorine, isolated from Crinum latifolium L. (family Amaryllidaceae) was studied on the rate of degranulation of mast cells of albino rats. Different combinations of glucan A and phosphatidyllycorine (5–20 and 5–10 μg/mL, respectively) in vitro , produced statistically significant protection against Tween 80‐induced degranulation, as well as to sensitized mast cells challenged with an antigen (horse serum). The combination (10–20 mg/kg), when administered in vivo , also provided protection against compound 48/80‐induced degranulation of mast cells. The findings are appraised in view of the use of the total extract of C. latifolium , for the treatment of allergic disorders in Ayurvedic medicine.

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