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Mast cell stabilizing effect of glucan A and phosphatidyllycorine isolated from Crinum latifolium
Author(s) -
Ghosal Shibnath,
Shanthy Amirthalingam,
Das Prasun K.,
Mukhopadhyay Mita,
Sarkar Mihir K.
Publication year - 1988
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650020206
Subject(s) - degranulation , amaryllidaceae , mast cell , in vivo , traditional medicine , pharmacognosy , in vitro , glucan , pharmacology , biology , chemistry , medicine , immunology , biological activity , biochemistry , botany , receptor , microbiology and biotechnology
The effect of glucan A and phosphatidyllycorine, isolated from Crinum latifolium L. (family Amaryllidaceae) was studied on the rate of degranulation of mast cells of albino rats. Different combinations of glucan A and phosphatidyllycorine (5–20 and 5–10 μg/mL, respectively) in vitro , produced statistically significant protection against Tween 80‐induced degranulation, as well as to sensitized mast cells challenged with an antigen (horse serum). The combination (10–20 mg/kg), when administered in vivo , also provided protection against compound 48/80‐induced degranulation of mast cells. The findings are appraised in view of the use of the total extract of C. latifolium , for the treatment of allergic disorders in Ayurvedic medicine.