Premium
CNS depressant effects, anti‐inflammatory activity and anti‐cholinergic actions of Santolina chamaecyparissus extracts
Author(s) -
Giner R. M.,
Ríos J. L.,
Villar A.
Publication year - 1988
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650020106
Subject(s) - pharmacology , oxytocin , depressant , duodenum , cholinergic , anti inflammatory , pharmacognosy , contraction (grammar) , traditional medicine , medicine , uterus , biological activity , chemistry , in vitro , endocrinology , biochemistry
The pharmacological activity of several extracts together with the lyophilized infusion of S. chamaecyparissus ssp. squarrosa were investigated. The lethal dose 50% (LD 50 ), effect on animal metabolism, mechanical and thermic analgesia and spontaneous, anti‐inflammatory, and anti‐ulcer activity have been determined. Studies on isolated organs (rat duodenum and rat uterus) were also carried out. The hexanic and chloroformic extracts were potent antagonists of the thermic analgesia test; the former extract was also active in the mechanical analgesia test. The chloroformic extract and, to a lesser extent, the ethyl acetate extract and lyophilized infusion demonstrated noteworthy activity as anti‐inflammatory agents. No extract produced an ulcerogenic effect. The hexanic extract had the highest inhibitory effect on ACh induced contraction of rat duodenum and the ethyl acetate extract of oxytocin induced contraction of rat uterus.