In vitro  cytotoxicity testing of natural products using guinea‐pig ear keratinocytes | Zendy

Harris Ann | Zendy; Keene Alison T. | Zendy; Phillipson J. David | Zendy; Warhurst David C. | Zendy

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In vitro cytotoxicity testing of natural products using guinea‐pig ear keratinocytes

Author(s) -

Harris Ann,

Keene Alison T.,

Phillipson J. David,

Warhurst David C.

Publication year - 1988

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2650020103

Subject(s) - guinea pig , in vitro , cytotoxicity , pharmacology , colchicine , ajmaline , pharmacognosy , berberine , vincristine , emetine , apocynaceae , alkaloid , quinine , biology , traditional medicine , chemistry , biochemistry , medicine , biological activity , stereochemistry , immunology , chemotherapy , endocrinology , neuroscience , genetics , malaria , cyclophosphamide

A simple test is described in which the inhibition of uptake of [G‐ 3 H]thymidine into guinea‐pig ear keratinocytes in vitro , has been used as an assessment for cytotoxicity of a series of alkaloids. The alkaloids tested include emetine, colchicine, coronaridine, ajmaline, aricine, vincristine, leurosine, quinamine, 3‐epiquinamine, quinine, quinidinone, cichonidine, berberine and atropine.

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