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Natural antagonists of platelet‐activating factor
Author(s) -
Hosford David,
MenciaHuerta JeanMichel,
Page Clive,
Braquet Pierre
Publication year - 1988
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650020102
Subject(s) - ginkgolides , platelet activating factor , biological activity , gliotoxin , chemistry , pharmacology , receptor , platelet activating factor receptor , platelet , stereochemistry , antagonist , biochemistry , biology , in vitro , immunology , ginkgo biloba , aspergillus fumigatus
Several groups of antagonists of platelet‐activating factor (PAF) are reviewed. The characteristics of PAF binding sites on mammalian cell membranes are described together with the activities of non‐specific and synthetic PAF‐antagonists. The specificity of the ginkgolides to bind to PAF‐receptors is discussed and the effects of these natural products in a range of biological systems is emphasized. Other groups of natural PAF‐antagonists described are the lignans and gliotoxin related compounds. The structural chemistry, structure‐activity relationships and pharmacological properties of these drugs are compared to the ginkgolides.