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Central actions of adenosine, a nucleotide of Ganoderma lucidum
Author(s) -
Kasahara Yoshimasa,
Hikino Hiroshi
Publication year - 1987
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650010409
Subject(s) - adenosine , ganoderma lucidum , caffeine , inhibitory postsynaptic potential , chemistry , traditional medicine , pharmacology , biological activity , biology , biochemistry , medicine , in vitro , endocrinology
In order to isolate an active constituent from the central inhibitory Ganoderma extract, an activity‐guided fractionation was performed to yield adenosine. Adenosine reduced spontaneous motor activity, elevated pain threshold, prolonged the death time induced by caffeine and relaxed skeletal muscle in mice.