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Estrogenic and anticonceptive activity of a petroleum ether soluble fraction of Malvaviscus conzattii Greenum flowers in female rats
Author(s) -
Bhargava S. K.
Publication year - 1987
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650010404
Subject(s) - ovariectomized rat , petroleum ether , ether , pregnancy , endocrinology , chemistry , biological activity , medicine , fraction (chemistry) , estrogen , pharmacology , biology , in vitro , chromatography , biochemistry , organic chemistry , genetics , extraction (chemistry)
Abstract A petroleum ether soluble fraction Fr. III isolated from the benzene extract of Malvaviscus conzattii Greenum flowers and administered orally to adult female rats at the doses of 10, 20 and 40 mg/rat from day 1 to day 5 of pregnancy showed 50%, 60% and 80% anti‐implantation, as well as 60%, 80% and 100% anticonceptive activity in the treated animals, respectively. There was a dose dependent termination of pregnancy and reduction in the number of implantation sites. In ovariectomized young female rats, the Fr. III exhibited estrogenic activity at comparable anticonceptive doses, but was devoid of antiestrogenic activity. Fr. III seems to possess a weak estrogenic activity in that a significant uterotrophic effect was discerned even at 1/16th of the anticonceptive dose.