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Pharmacological investigations of Hibiscus micranthus Linn., a febrifuge used in Saudi Arabian folk medicine
Author(s) -
AlYahya M. A.,
Tariq M.,
Parmar N. S.,
Ageel A. M.
Publication year - 1987
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650010207
Subject(s) - chronotropic , traditional medicine , medicine , analgesic , pharmacology , inotrope , stimulant , heart rate , blood pressure
The ethanolic extract of Hibiscus micranthus Linn. has been studied for its pharmacological activities. It has been found to produce significant inhibition of carrageenan induced paw oedema and cotton pellet induced granuloma pouch in rats and significant reduction in yeast induced hyperpyrexia in mice. It failed to produce any analgesic activity on the hot plate reaction time test in mice. On the hematological and biochemical parameters it produced a significant prolongation of prothrombin time, a decrease in the fibrinogen content and marked hyperglycemia in rats. It also produced significant neuromuscular blocking activity on both the models used in this study. Apart from these, it exhibited slight inotropic and chronotropic effects on isolated rabbit heart and a mild CNS stimulant effect. Further studies on the isolation of its active phytoconstituents and their pharmacological actions are being undertaken.