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The schizontocidal activity of Spathodea campanulata leaf extract on Plasmodium berghei berghei in mice
Author(s) -
Makinde J. M.,
Adesogan E. K.,
Amusan O. O. G.
Publication year - 1987
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650010205
Subject(s) - plasmodium berghei , traditional medicine , decoction , chloroquine , anti malarial , malaria , biology , aqueous extract , malarial parasites , medicine , pharmacology , immunology , plasmodium falciparum
Effects of extracts of Spathodea campanulata on Plasmodium berghei berghei in mice have been investigated. Schizontocidal activity of the plant in blood was determined on both the early and established infections. The repository action of the plant was also investigated. Chloroquine and pyrimethamine were used as reference drugs. The alcoholic extract of the leaves of the plant demonstrated antiplasmodial activity. The plant extract was more effective in treating the early infection than the established one. This report provides scientific data for the use of the aqueous alcoholic decoction of the leaves of Spathodea campanulata for the treatment of malaria.