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Effects of baicalein on leukotriene C 4 biosynthesis in human lymphocytes
Author(s) -
Kimura Yoshiyuki,
Okuda Hiromichi,
Arichi Shigeru
Publication year - 1987
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650010111
Subject(s) - baicalein , ionophore , biosynthesis , leukotriene , calcium , chemistry , pharmacology , biochemistry , biology , immunology , enzyme , organic chemistry , asthma
Studies were made on the effects of baicalein (5,6,7‐trihydroxyflavone) on leukotriene C 4 (LTC 4 ) biosynthesis by calcium ionophore A 23187 in human lymphocytes. Baicalein inhibited calcium ionophore‐induced LTC 4 biosynthesis in human lymphocytes. The concentration of baicalein required for 50% inhibition (IC 50 ) of LTC 4 formation was 4.3 × 10 −7 M.