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Toxicological assessment of beta‐lapachone on organs from pregnant and non‐pregnant rats
Author(s) -
de Almeida Edvaldo Rodrigues,
Lucena Flávia Raquel Santos,
Silva Camilla Vila Nova Soares,
da Silva CostaJunior Wilson,
Cavalcanti Jouse Bezerra,
Couto Gerald Bosco Lindoso,
da Silva Luiz Lúcio Soares,
da Mota Diógenes Luís,
da Silveira Alex Benício,
de Sousa Filho Samuel Daniel,
da Silva Aldo Cezar Passilongo
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2646
Subject(s) - alkaline phosphatase , teratology , pharmacology , enzyme , hematology , transaminase , kidney , spleen , pregnancy , gestation , chemistry , biology , medicine , endocrinology , biochemistry , genetics
Naphthoquinones have been studied extensively due to their activity as topoisomerase inhibitors. These enzymes are critical to DNA replication in cells. β ‐Lapachone (beta‐lap) is an o ‐naphthoquinone chemically obtained from lapachol. This work results in a toxicological evaluation of beta‐lap in Wistar rats observing the following parameters: teratology, histology, hematology and serum biochemistry. The data demonstrate teratogenic action at the doses used, as well as hematological alterations in the total leukocytes, monocytes and segmented. The biochemical data demonstrated an increase in gamma glutamyl transferase, alkaline phosphatase and glutamate pyruvate transaminase levels. Histological study showed significant alterations in the spleen, however, the liver and kidney did not present significant alterations. Copyright © 2009 John Wiley & Sons, Ltd.