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Naringin ameliorates mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol‐induced myocardial infarction in Wistar rats
Author(s) -
Rajadurai M.,
Prince P. Stanely Mainzen
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2632
Subject(s) - naringin , chemistry , glutathione peroxidase , glutathione , superoxide dismutase , antioxidant , catalase , pharmacology , lipid peroxide , biochemistry , mitochondrion , endocrinology , medicine , enzyme , biology , chromatography
The present study was undertaken to evaluate the preventive role of naringin on mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol (ISO)‐induced myocardial infarction (MI) in male Wistar rats. Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for 2 days resulted in a significant increase in the levels of mitochondrial lipid peroxides with a significant decrease in the activities/levels of mitochondrial antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione‐S‐transferase and reduced glutathione). ISO‐induction also showed a significant increase in the levels of mitochondrial cholesterol, triglycerides and free fatty acids with a subsequent decrease in the levels of phospholipids. Oral pretreatment with naringin (10, 20 and 40 mg/kg) to ISO‐induced rats daily for a period of 56 days significantly decreased the levels of mitochondrial lipid peroxides with a significant increase in the activities/levels of mitochondrial antioxidants and significantly minimized the alterations in the mitochondrial lipid levels in ISO‐induced rats. Thus, the findings demonstrate that naringin prevents alterations in mitochondrial lipid peroxides, antioxidants and lipids in ISO‐induced MI in rats. Copyright © 2008 John Wiley & Sons, Ltd.