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Antidiabetic effect of Olea europaea L. in normal and diabetic rats
Author(s) -
Eidi A.,
Eidi M.,
Darzi R.
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2629
Subject(s) - olea , glibenclamide , uric acid , urea , streptozotocin , diabetes mellitus , creatinine , endocrinology , uricosuric , medicine , cholesterol , oleaceae , chemistry , biochemistry , hyperuricemia , biology , botany
The antidiabetic effect of an alcohol extract of olive ( Olea europaea L.) leaves was investigated in normal and streptozotocin‐induced diabetic rats. The oral administration of the olive leaves extract (0.1, 0.25 and 0.5 g/kg body wt) for 14 days significantly decreased the serum glucose, total cholesterol, triglycerides, urea, uric acid, creatinine, aspartate amino transferase (AST) and alanine amino transferase (ALT) while it increased the serum insulin in diabetic rats but not in normal rats ( p < 0.05). A comparison was made between the action of olive leaves extract and glibenclamide (600 µg/kg), a known antidiabetic drug. The antidiabetic effect of the extract was more effective than that observed with glibenclamide. Copyright © 2008 John Wiley & Sons, Ltd.