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Improvement of seminal parameters with Prelox ® : a randomized, double‐blind, placebo‐controlled, cross‐over trial
Author(s) -
Stanislavov R.,
Nikolova V.,
Rohdewald P.
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2592
Subject(s) - placebo , semen , infertility , male infertility , medicine , fertility , semen analysis , placebo controlled study , double blind , urology , gynecology , andrology , biology , pregnancy , population , pathology , alternative medicine , environmental health , genetics
In a randomly allocated, double‐blind, placebo‐controlled, cross‐over design, 50 infertile patients were treated for 1 month with placebo or a combination of l ‐arginine aspartate and Pycnogenol ® (Prelox ® ). Semen samples were examined at 4 week intervals according to WHO criteria. Treatment with Prelox increased significantly the semen volume, concentration of spermatozoa, percentage of motile spermatozoa and percentage of spermatozoa with normal morphology compared with placebo. The placebo had no influence on the parameters of seminological analysis. Intake of Pycnogenol for 1 month improved the fertility index to normal values. After treatment, the fertility index decreased again to infertile status. No unwanted effects were reported. Prelox seems to be a promising alternative to treat patients with mild infertility. Copyright © 2009 John Wiley & Sons, Ltd.