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Kinetics of enzyme inhibition by active molluscicidal agents ferulic acid, umbelliferone, eugenol and limonene in the nervous tissue of snail Lymnaea acuminata
Author(s) -
Kumar Pradeep,
Singh V. K.,
Singh D. K.
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2578
Subject(s) - umbelliferone , eugenol , ferulic acid , limonene , non competitive inhibition , chemistry , biochemistry , alkaline phosphatase , biology , enzyme , coumarin , organic chemistry , food science , essential oil
Ferulic acid, umbelliferone ( Ferula asafoetida ), eugenol ( Syzygium aromaticum ) and limonene ( Carum carvi ) are active molluscicidal components that inhibited the activity of alkaline phosphatase and acetylcholinesterase in in vivo and in vitro exposure of Lymnaea acuminata . It was observed that ferulic acid, umbelliferone and eugenol are competitive and limonene is a competitive–non‐competitive inhibitor of alkaline phosphatase. Ferulic acid and umbelliferone are competitive, whereas eugenol and limonene are competitive–non‐competitive and uncompetitive inhibitors of acetylcholinesterase, respectively. Copyright © 2008 John Wiley & Sons, Ltd.