Furostanol saponins and ecdysones with cytotoxic activity from  Helleborus bocconei  ssp.  intermedius | Zendy

Rosselli Sergio | Zendy; Maggio Antonella | Zendy; Bruno Maurizio | Zendy; Spadaro Vivienne | Zendy; Formisano Carmen | Zendy; Irace Carlo | Zendy; Maffettone Carmen | Zendy; Mascolo Nicola | Zendy

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Furostanol saponins and ecdysones with cytotoxic activity from Helleborus bocconei ssp. intermedius

Author(s) -

Rosselli Sergio,

Maggio Antonella,

Bruno Maurizio,

Spadaro Vivienne,

Formisano Carmen,

Irace Carlo,

Maffettone Carmen,

Mascolo Nicola

Publication year - 2009

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2569

Subject(s) - ranunculaceae , saponin , cytotoxicity , traditional medicine , chemistry , pharmacognosy , glycoside , stereochemistry , biology , botany , biological activity , biochemistry , in vitro , medicine , alternative medicine , pathology

Two furostanol saponins helleboroside A (1) and helleboroside B (2) were isolated from the methanol extract of Helleborus bocconei Ten. subsp. intermedius (Guss.) Greuter and Burdet, along with the furospirostanol saponin 4 and two ecdysones: ecdysterone (5) and polypodyne B (6). Compound 2 was enzymatically hydrolysed to give product 3. The biological activity of all compounds was tested against rat C6 glioma cells showing a significant cytotoxicity for compounds 3, 4 and 6. Copyright © 2009 John Wiley & Sons, Ltd.

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