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Furostanol saponins and ecdysones with cytotoxic activity from Helleborus bocconei ssp. intermedius
Author(s) -
Rosselli Sergio,
Maggio Antonella,
Bruno Maurizio,
Spadaro Vivienne,
Formisano Carmen,
Irace Carlo,
Maffettone Carmen,
Mascolo Nicola
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2569
Subject(s) - ranunculaceae , saponin , cytotoxicity , traditional medicine , chemistry , pharmacognosy , glycoside , stereochemistry , biology , botany , biological activity , biochemistry , in vitro , medicine , alternative medicine , pathology
Two furostanol saponins helleboroside A (1) and helleboroside B (2) were isolated from the methanol extract of Helleborus bocconei Ten. subsp. intermedius (Guss.) Greuter and Burdet, along with the furospirostanol saponin 4 and two ecdysones: ecdysterone (5) and polypodyne B (6). Compound 2 was enzymatically hydrolysed to give product 3. The biological activity of all compounds was tested against rat C6 glioma cells showing a significant cytotoxicity for compounds 3, 4 and 6. Copyright © 2009 John Wiley & Sons, Ltd.