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Radioprotective effects of fucoidan in mice treated with total body irradiation
Author(s) -
Lee Jeeyoung,
Kim Jeongtae,
Moon Changjong,
Kim SungHo,
Hyun Jin Won,
Park Jae Woo,
Shin Taekyun
Publication year - 2008
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2562
Subject(s) - fucoidan , total body irradiation , bone marrow , haematopoiesis , pharmacology , body weight , irradiation , ratón , chemistry , biology , medicine , immunology , endocrinology , chemotherapy , polysaccharide , biochemistry , stem cell , genetics , physics , nuclear physics , cyclophosphamide
The effects of fucoidan on the survival rate of mice treated with total body irradiation were examined. BALB/c mice were pretreated with various doses of fucoidan prior to total‐body irradiation and were monitored for 30 days. A significant improvement of survival was observed by pretreatment with fucoidan at 100 mg/kg body weight. Using this optimal dosage, survival was examined by radiation dose reduction analysis and a dose reduction factor (DRF) of 1.20 was determined at 30 days post‐irradiation. Mice pretreated with fucoidan also exhibited dose‐dependent increases in the number of bone marrow cells and endogenous spleen cell colonies at day 9 post‐irradiation. It is concluded that the increased survival of whole‐body irradiated mice pretreated with fucoidan may be attributable to the radioprotective effects of fucoidan on hematopoietic cell viability, proliferation and/or mobility, possibly through antioxidation or antiinflammatory mechanisms. Copyright © 2008 John Wiley & Sons, Ltd.