In vitro  antiprotozoal activity of some xanthones isolated from the roots of  Andrographis paniculata | Zendy

Dua Virendra K. | Zendy; Verma Gaurav | Zendy; Dash A. P. | Zendy

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In vitro antiprotozoal activity of some xanthones isolated from the roots of Andrographis paniculata

Author(s) -

Dua Virendra K.,

Verma Gaurav,

Dash A. P.

Publication year - 2009

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2556

Subject(s) - antiprotozoal , andrographis paniculata , trypanosoma brucei , andrographolide , traditional medicine , in vitro , leishmania donovani , leishmania infantum , trypanosoma cruzi , xanthone , biology , chemistry , pharmacology , biochemistry , stereochemistry , leishmaniasis , medicine , parasite hosting , immunology , visceral leishmaniasis , alternative medicine , pathology , gene , world wide web , computer science

Four xanthones isolated from the roots of Andrographis paniculata were tested in vitro for antiprotozoal activity against Trypanosoma brucei brucei , Trypanosoma cruzi and Leishmania infantum . Compound TDR13011 (1,2‐dihydroxy‐6,8‐dimethoxy‐xanthone) showed good activity against T. b. brucei and L. infantum with a 50% inhibitory concentration (IC 50 ) of 4.6 µg/ml and 8 µg/ml respectively. Xanthones from the roots of Andrographis paniculata exhibited promising anti‐protozoal activity and these compounds could be chemically modified to obtain a more potent product. Copyright © 2008 John Wiley & Sons, Ltd.

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