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In vitro antiprotozoal activity of some xanthones isolated from the roots of Andrographis paniculata
Author(s) -
Dua Virendra K.,
Verma Gaurav,
Dash A. P.
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2556
Subject(s) - antiprotozoal , andrographis paniculata , trypanosoma brucei , andrographolide , traditional medicine , in vitro , leishmania donovani , leishmania infantum , trypanosoma cruzi , xanthone , biology , chemistry , pharmacology , biochemistry , stereochemistry , leishmaniasis , medicine , parasite hosting , immunology , visceral leishmaniasis , alternative medicine , pathology , gene , world wide web , computer science
Four xanthones isolated from the roots of Andrographis paniculata were tested in vitro for antiprotozoal activity against Trypanosoma brucei brucei , Trypanosoma cruzi and Leishmania infantum . Compound TDR13011 (1,2‐dihydroxy‐6,8‐dimethoxy‐xanthone) showed good activity against T. b. brucei and L. infantum with a 50% inhibitory concentration (IC 50 ) of 4.6 µg/ml and 8 µg/ml respectively. Xanthones from the roots of Andrographis paniculata exhibited promising anti‐protozoal activity and these compounds could be chemically modified to obtain a more potent product. Copyright © 2008 John Wiley & Sons, Ltd.