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Search for antimycobacterial constituents from a Tibetan medicinal plant, Gentianopsis paludosa
Author(s) -
Yeung MingFai,
Lau Clara B. S.,
Chan Raphael C. Y.,
Zong Yuying,
Che ChunTao
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2506
Subject(s) - antimycobacterial , oleanolic acid , traditional medicine , mycobacterium tuberculosis , mycobacterium smegmatis , luteolin , gentianaceae , minimum inhibitory concentration , biology , chemistry , botany , microbiology and biotechnology , tuberculosis , antimicrobial , biochemistry , flavonoid , medicine , antioxidant , alternative medicine , pathology
From the whole plant of Gentianopsis paludosa seven compounds were isolated and identified to be 1,7‐dihydroxy‐3,8‐dimethoxyxanthone (1), 1,7,8‐trihydroxy‐3‐methoxyxanthone (2), 1‐hydroxy‐3,7,8‐trimethoxyxanthone (3), 1,8‐dihydroxy‐2,6‐dimethoxyxanthone (4), oleanolic acid (5), 4′,5,7‐trihydroxyflavone (6) and luteolin‐7‐O‐glucoside (7). Compounds 1, 2, 3 and 5 showed modest inhibitory effect against the growth of Mycobacterium smegmatis and M. tuberculosis . Copyright © 2008 John Wiley & Sons, Ltd.