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Antifungal activity of alkanols against Zygosaccharomyces bailii and their effects on fungal plasma membrane
Author(s) -
Fujita KenIchi,
Fujita Tomoko,
Kubo Isao
Publication year - 2008
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2500
Subject(s) - fungicide , saccharomyces cerevisiae , food spoilage , chemistry , biochemistry , minimum inhibitory concentration , membrane , antifungal , yeast , biology , microbiology and biotechnology , in vitro , botany , bacteria , genetics
A series of aliphatic primary alkanols from C 6 to C 13 were tested for antifungal activity against a food spoilage fungus Zygosaccharomyces bailii using a broth dilution method and were compared for their effects against Saccharomyces cerevisiae and Z. rouxii . Decanol (C 10 ) was found to be the most potent fungicide against Z. bailii at a minimum fungicidal concentration of 50 µg/ml (0.31 mM), whereas undecanol (C 11 ) was found to be the most potent fungistatic at a minimum inhibitory concentration of 25 µg/ml (0.14 mM). The time‐kill curve study showed that decanol was fungicidal against Z . bailii at any growth stage. Octanol (C 8 ) increased plasma membrane fluidity in the spheroplast cells of S. cerevisiae . The primary antifungal action of alkanols comes from their ability to disrupt the native membrane‐associated function of integral proteins nonspecifically as nonionic surface‐active agents (surfactants). The antifungal activity of decanol against Z. bailii was slightly enhanced in combination with anethole. Copyright © 2008 John Wiley & Sons, Ltd.