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Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus‐castus
Author(s) -
Mesaik M. Ahmed,
Murad Shahnaz,
Khan Khalid Mohammed,
Tareen Rasool Bakhsh,
Ahmed Aqeel,
Choudhary Muhammad Iqbal
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2492
Subject(s) - flavonoid , chemistry , chemiluminescence , cytotoxicity , pharmacology , traditional medicine , in vitro , chemotaxis , vitex , monocyte , biochemistry , biology , medicine , immunology , antioxidant , chromatography , receptor
Casticin (1), a flavonoid isolated from the aerial parts of Vitex agnus‐castus , was found to be a potent immunomodulatory and cytotoxic compound. The activity was tested in vitro for chemiluminescence, chemotaxis, T‐cell proliferation and cytotoxicity. Casticin (1) exhibited a significant inhibitory effect on monocyte oxidative burst in a dose dependent manner. It was found to have a significant suppressive effect on the chemotaxic action at higher concentrations on fMLP (10 −8 m ) stimulated neutrophils. It also showed a potent suppressive effect on PHA stimulated T‐cell (PMBC). Copyright © 2009 John Wiley & Sons, Ltd.