Isolation and immunomodulatory properties of a flavonoid, casticin from  Vitex agnus‐castus | Zendy

Mesaik M. Ahmed | Zendy; Murad Shahnaz | Zendy; Khan Khalid Mohammed | Zendy; Tareen Rasool Bakhsh | Zendy; Ahmed Aqeel | Zendy; Choudhary Muhammad Iqbal | Zendy

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Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus‐castus

Author(s) -

Mesaik M. Ahmed,

Murad Shahnaz,

Khan Khalid Mohammed,

Tareen Rasool Bakhsh,

Ahmed Aqeel,

Choudhary Muhammad Iqbal

Publication year - 2009

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2492

Subject(s) - flavonoid , chemistry , chemiluminescence , cytotoxicity , pharmacology , traditional medicine , in vitro , chemotaxis , vitex , monocyte , biochemistry , biology , medicine , immunology , antioxidant , chromatography , receptor

Casticin (1), a flavonoid isolated from the aerial parts of Vitex agnus‐castus , was found to be a potent immunomodulatory and cytotoxic compound. The activity was tested in vitro for chemiluminescence, chemotaxis, T‐cell proliferation and cytotoxicity. Casticin (1) exhibited a significant inhibitory effect on monocyte oxidative burst in a dose dependent manner. It was found to have a significant suppressive effect on the chemotaxic action at higher concentrations on fMLP (10 −8 m ) stimulated neutrophils. It also showed a potent suppressive effect on PHA stimulated T‐cell (PMBC). Copyright © 2009 John Wiley & Sons, Ltd.

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