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Antiparasitic, nematicidal and antifouling constituents from Juniperus berries
Author(s) -
Samoylenko Volodymyr,
Dunbar D. Chuck,
Gafur Md. Abdul,
Khan Shabana I.,
Ross Samir A.,
Mossa Jaber S.,
ElFeraly Farouk S.,
Tekwani Babu L.,
Bosselaers Jan,
Muhammad Ilias
Publication year - 2008
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2460
Subject(s) - abietane , diterpene , labdane , artemia salina , chemistry , exudate , terpenoid , antiparasitic , traditional medicine , terpene , botany , biology , stereochemistry , organic chemistry , toxicity , medicine , pathology
A bioassay‐guided fractionation of Juniperus procera berries yielded antiparasitic, nematicidal and antifouling constituents, including a wide range of known abietane, pimarane and labdane diterpenes. Among these, abieta‐7,13‐diene (1) demonstrated in vitro antimalarial activity against Plasmodium falciparum D6 and W2 strains (IC 50 = 1.9 and 2.0 µg/mL, respectively), while totarol (6), ferruginol (7) and 7 β ‐hydroxyabieta‐8,13‐diene‐11,12‐dione (8) inhibited Leishmania donovani promastigotes with IC 50 values of 3.5–4.6 µg/mL. In addition, totarol demonstrated nematicidal and antifouling activities against Caenorhabditis elegans and Artemia salina at a concentration of 80 µg/mL and 1 µg/mL, respectively. The resinous exudate of J. virginiana afforded known antibacterial E ‐communic acid (4) and 4‐ epi ‐abietic acid (5), while the volatile oil from its trunk wood revealed large quantities of cedrol (9). Using GC/MS, the two known abietanes totarol (6) and ferruginol (7) were identified from the berries of J. procera , J. excelsa and J. phoenicea . Copyright © 2008 John Wiley & Sons, Ltd.
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