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An Iranian herbal‐marine medicine, MS 14 , ameliorates experimental allergic encephalomyelitis
Author(s) -
Tafreshi Azita Parvaneh,
Ahmadi Amrollah,
Ghaffarpur Majid,
Mostafavi Hossein,
Rezaeizadeh Hossein,
Minaie Bagher,
Faghihzadeh Soghrat,
Naseri Mohsen
Publication year - 2008
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2459
Subject(s) - multiple sclerosis , encephalomyelitis , medicine , experimental autoimmune encephalomyelitis , disease , central nervous system , demyelinating disease , immunology , pharmacology
Multiple sclerosis is an inflammatory and demyelinating disease of the central nervous system which mainly affects young adults. To overcome wide spectrum troublesome symptoms of multiple sclerosis which affects the quality of life both in patients and their families, new drugs and remedies have been examined and offered. The preclinical beneficial effects of different medicines have mostly been examined in an animal model of multiple sclerosis called experimental allergic encephalomyelitis (EAE). In this study we have tested a traditionally used natural (herbal‐marine) product called MS 14 in EAE mice. EAE mice were fed with MS 14 containing diet (30%) on the immunization day and monitored for 20 days. The results show that while clinical scores and therefore severity of the disease was progressive in normal‐fed EAE mice, the disease was slowed down in MS 14 ‐fed EAE mice. Moreover, while there were moderate to severe neuropathological changes in normal fed mice, milder changes were seen in MS 14 fed mice. Copyright © 2008 John Wiley & Sons, Ltd.