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Antibacterial potential of Antarctic lichens against human pathogenic Gram‐positive bacteria
Author(s) -
Paudel Babita,
Bhattarai Hari Datta,
Lee Jin Sung,
Hong Soon Gyu,
Shin Hyun Woung,
Yim Joung Han
Publication year - 2008
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2445
Subject(s) - lichen , minimum inhibitory concentration , antibacterial activity , bacteria , antimicrobial , gram , biology , botany , agar diffusion test , mycology , traditional medicine , usnic acid , microbiology and biotechnology , chemistry , medicine , genetics
Extracts from five Antarctic lichens (L3, Stereocaulon alpinum ; L5, Ramalina terebrata ; L6, Caloplaca sp.; L8, Lecanora sp.; and L17, Caloplaca regalis ) were tested for antimicrobial activities against several clinically important microbes by disk diffusion. The minimum inhibitory concentration (MIC) of each extract was determined by a broth dilution method. Extracts from L3, L5, L6 and L8 were active against two Gram(+) strains. B. subtilis was more sensitive to lichen extracts (except L5) than S. aureus . The MIC of lichen extracts against B. subtilis and S. aureus was observed from 36.7 ± 0.3 to 953.8 ± 85.8 µg/mL and 68.5 ± 0.6 to >1000 µg/mL, respectively. Comparisons of MIC values of Antarctic lichen crude extracts to previously published MIC values of some reported lichen metabolites against Gram(+) bacteria indicated that Antarctic lichens might be an enriched source of effective antibacterial agents against clinically relevant Gram(+) species. Copyright © 2008 John Wiley & Sons, Ltd.