Antioxidant and cytoprotective compounds from  Berberis vulgaris  (barberry) | Zendy

Tomosaka Hideyuki | Zendy; Chin YoungWon | Zendy; Salim Angela A. | Zendy; Keller William J. | Zendy; Chai Heebyung | Zendy; Kinghorn A. Douglas | Zendy

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Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry)

Author(s) -

Tomosaka Hideyuki,

Chin YoungWon,

Salim Angela A.,

Keller William J.,

Chai Heebyung,

Kinghorn A. Douglas

Publication year - 2008

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2443

Subject(s) - antioxidant , hydrogen peroxide , berberidaceae , bark (sound) , chemistry , traditional medicine , fractionation , tyramine , bioassay , polyphenol , biological activity , botany , biochemistry , biology , chromatography , in vitro , medicine , ecology , genetics

Activity‐guided fractionation of an EtOAc‐soluble partition of the MeOH extract from the root bark of Berberis vulgaris L. (barberry), using a hydroxyl radical‐scavenging assay, led to the isolation and identification of three phenolic compounds of a previously known structure, N ‐( p ‐ trans ‐coumaroyl)tyramine, cannabisin G and (±)‐lyoniresinol. Of these, cannabisin G and (±)‐lyoniresinol exhibited antioxidant activity in this bioassay. Furthermore, it was found that cannabisin G showed cytoprotective activity in cultured MCF‐7 cells modulated by hydrogen peroxide. Copyright © 2008 John Wiley & Sons, Ltd.

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