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Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry)
Author(s) -
Tomosaka Hideyuki,
Chin YoungWon,
Salim Angela A.,
Keller William J.,
Chai Heebyung,
Kinghorn A. Douglas
Publication year - 2008
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2443
Subject(s) - antioxidant , hydrogen peroxide , berberidaceae , bark (sound) , chemistry , traditional medicine , fractionation , tyramine , bioassay , polyphenol , biological activity , botany , biochemistry , biology , chromatography , in vitro , medicine , ecology , genetics
Activity‐guided fractionation of an EtOAc‐soluble partition of the MeOH extract from the root bark of Berberis vulgaris L. (barberry), using a hydroxyl radical‐scavenging assay, led to the isolation and identification of three phenolic compounds of a previously known structure, N ‐( p ‐ trans ‐coumaroyl)tyramine, cannabisin G and (±)‐lyoniresinol. Of these, cannabisin G and (±)‐lyoniresinol exhibited antioxidant activity in this bioassay. Furthermore, it was found that cannabisin G showed cytoprotective activity in cultured MCF‐7 cells modulated by hydrogen peroxide. Copyright © 2008 John Wiley & Sons, Ltd.