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Elaeocarpus sylvestris modulates gamma‐ray‐induced immunosuppression in mice: implications in radioprotection
Author(s) -
Park Eunjin,
Lee Nam Ho,
Baik Jong Seok,
Jee Youngheun
Publication year - 2008
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2430
Subject(s) - immunosuppression , pharmacognosy , biology , pharmacology , medicine , immunology , biological activity , genetics , in vitro
The study investigated the potential of Elaeocarpus sylvestris var. ellipticus (E.S.), which contains 1,2,3,4,6‐penta‐ O ‐galloyl‐beta‐ d ‐glucose (PGG), to protect mice from radiation injury by single whole‐body irradiation (WBI) in vivo. The results from the present study demonstrate that the E.S. extract significantly improved the rate and duration of survival beyond that of untreated, irradiated control mice. The counts of endogenous colony forming units (CFU) increased in E.S.‐treated mice, indicating that E.S. induced the regeneration of hematopoietic cells. E.S. treatment also accelerated the proliferation and recovery of lymphocytes and granulocytes, compared with those levels in untreated, irradiated controls. These results suggest that E.S. extract increases the survival time of mammals exposed to ionizing radiation by intensifying the victims' hematopoietic repair capacities. Therefore, it is concluded that the E.S. extract may be an effective agent of protection from radiation‐induced injuries. Copyright © 2008 John Wiley & Sons, Ltd.