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Dietary red chilli ( Capsicum frutescens L.) is insulinotropic rather than hypoglycemic in type 2 diabetes model of rats
Author(s) -
Islam Md. Shahidul,
Choi Haymie
Publication year - 2008
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2417
Subject(s) - streptozotocin , medicine , diabetes mellitus , endocrinology , type 2 diabetes , glycogen , hemoglobin , insulin , type 1 diabetes
The present study was conducted to clarify whether a low or a high, but tolerable, dietary dose of red chilli (RC) can ameliorate the diabetes related complications in a high‐fat (HF) diet‐fed streptozotocin (STZ)‐induced type 2 diabetes model of rats. Five‐week‐old male Sprague Dawley rats were fed a HF diet for 2 weeks then randomly divided into four groups namely: normal control (NC), diabetic control (DBC), red chilli low (RCL, 0.5%) and red chilli high (RCH, 2.0%) groups. Diabetes was induced by an intraperitoneal (i.p.) injection of STZ (40 mg/kg BW) in all groups except the NC group. After 4 weeks feeding of experimental diets, the fasting blood glucose concentrations in both RC fed groups were not significantly different. The serum insulin concentration was significantly ( p < 0.05) increased in the RCH group compared with the DBC and RCL groups. Blood HbA1c, liver weight, liver glycogen and serum lipids were not influenced by the feeding of RC‐containing diets. The data of this study suggest that 2% dietary RC is insulinotropic rather than hypoglycemic at least in this experimental condition. Copyright © 2008 John Wiley & Sons, Ltd.