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Ameliorating effect of balloon flower saponin on the ethanol‐induced memory impairment in mice
Author(s) -
Choi Yeon Hee,
Kim Young Sup,
Yeo Su Jeong,
Roh Seong Hwan,
Jeong Young Chul,
Kang Jong Seong,
Ryu Shi Yong
Publication year - 2008
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2394
Subject(s) - saponin , campanulaceae , ethanol , memory impairment , traditional medicine , chemistry , oral administration , pharmacology , medicine , biology , botany , biochemistry , cognition , pathology , alternative medicine , psychiatry
The ameliorating effect of the root extract of Platycodon grandiflorum (Campanulaceae) on ethanol‐induced cognitive dysfunction in mice was investigated. The mice with repeated administration of the root extract of P. grandiflorum , crude saponin fraction and platycoside E, a main ingredient of crude saponin fraction, showed a markedly prolonged step‐through latency period (STL) on the passive avoidance task performed after acute ethanol intoxication, respectively. The present results suggest that the memory enhancing effect of the extract was ascribed mainly to the saponin fraction and that saponin of P. grandiflorum , particularly platycoside E could exert a beneficial effect on memory impairment in mice. Copyright © 2008 John Wiley & Sons, Ltd.