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Chemoprotective effects of a protein from the red algae Porphyra yezoensis on acetaminophen‐induced liver injury in rats
Author(s) -
Hwang HyeJung,
Kwon MiJin,
Kim InHye,
Nam TaekJeong
Publication year - 2008
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2368
Subject(s) - dna fragmentation , liver injury , porphyra , acetaminophen , glutathione , liver tissue , fragmentation (computing) , pharmacology , medicine , biochemistry , biology , apoptosis , endocrinology , chemistry , algae , programmed cell death , enzyme , botany , ecology
Abstract Seaweeds contribute to the maintenance of health through their nutritional and medicinal properties. The effects of PYP, a 14 kDa protein isolated from a hot‐water extract of the marine alga Porphyra yezoensis , on AAP‐induced liver injury in rats was evaluated. AAP induced acute liver injury and AAP‐induced hepatotoxicity is the leading cause of liver failure. In this study, male Sprague–Dawley rats were assigned to one of three treatment groups: control, AAP, or AAP + PYP. Compared with the control group, liver tissue from the AAP group showed increased levels of caspase‐3 activity and DNA fragmentation, decreased levels of GSH and increased serum GOT/GPT levels. In contrast, treatment with AAP + PYP produced levels of caspase‐3 activity, DNA fragmentation, GSH and GOT/GPT that matched the values seen in the control group. It is concluded that PYP may prevent AAP‐induced liver injury. Copyright © 2008 John Wiley & Sons, Ltd.