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Antileishmanial, antiplasmodial and cytotoxic activities of 12,16‐dideoxy aegyptinone B from Zhumeria majdae Rech.f. & Wendelbo
Author(s) -
Moein Mahmood Reza,
Pawar Rahul S.,
Khan Shabana I.,
Tekwani Babu L.,
Khan Ikhlas A.
Publication year - 2008
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2305
Subject(s) - cytotoxicity , in vitro , cytotoxic t cell , pharmacology , chloroquine , fractionation , traditional medicine , cancer cell lines , chemistry , cell culture , ethanol , stereochemistry , biology , biochemistry , cancer cell , medicine , malaria , cancer , immunology , chromatography , genetics
The ethanol extract of Zhumeria majdae showed potent antileishmanial and antiplasmodial activity in vitro . Bioactivity guided fractionation of the extract led to the isolation of 12,16‐dideoxy aegyptinone B (1). This compound exhibited potent in vitro antileishmanial activity with an IC 50 of 0.75 µg/mL and a strong antiplasmodial activity with IC 50 values of 1.3 and 1.4 µg/mL against chloroquine sensitive and resistant strains, respectively. This compound was further found to have mild cytotoxicity towards cancer cell lines. Copyright © 2007 John Wiley & Sons, Ltd.