Antileishmanial, antiplasmodial and cytotoxic activities of 12,16‐dideoxy aegyptinone B from  Zhumeria majdae  Rech.f. & Wendelbo | Zendy

Moein Mahmood Reza | Zendy; Pawar Rahul S. | Zendy; Khan Shabana I. | Zendy; Tekwani Babu L. | Zendy; Khan Ikhlas A. | Zendy

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Antileishmanial, antiplasmodial and cytotoxic activities of 12,16‐dideoxy aegyptinone B from Zhumeria majdae Rech.f. & Wendelbo

Author(s) -

Moein Mahmood Reza,

Pawar Rahul S.,

Khan Shabana I.,

Tekwani Babu L.,

Khan Ikhlas A.

Publication year - 2008

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2305

Subject(s) - cytotoxicity , in vitro , cytotoxic t cell , pharmacology , chloroquine , fractionation , traditional medicine , cancer cell lines , chemistry , cell culture , ethanol , stereochemistry , biology , biochemistry , cancer cell , medicine , malaria , cancer , immunology , chromatography , genetics

The ethanol extract of Zhumeria majdae showed potent antileishmanial and antiplasmodial activity in vitro . Bioactivity guided fractionation of the extract led to the isolation of 12,16‐dideoxy aegyptinone B (1). This compound exhibited potent in vitro antileishmanial activity with an IC 50 of 0.75 µg/mL and a strong antiplasmodial activity with IC 50 values of 1.3 and 1.4 µg/mL against chloroquine sensitive and resistant strains, respectively. This compound was further found to have mild cytotoxicity towards cancer cell lines. Copyright © 2007 John Wiley & Sons, Ltd.

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