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Ganoderma applanatum : a promising mushroom for antitumor and immunomodulating activity
Author(s) -
Jeong YongTae,
Yang ByungKeun,
Jeong SangChul,
Kim SangMin,
Song ChiHyun
Publication year - 2008
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2294
Subject(s) - splenocyte , mushroom , ganoderma , biochemistry , mannose , chemistry , pharmacology , biology , in vitro , food science , ganoderma lucidum
The antitumor effect of exo‐biopolymer (EXP) produced by Ganoderma applanatum was investigated using sarcoma‐180 bearing mice. EXP, when administered (10–80 mg/kg body weight: BW) intraperitoneally, significantly inhibited the growth of solid tumor and increased the natural killer (NK) cell activity. A dose of 40 mg/kg BW was found to be highly effective, as it reduced the tumor formation by 39.7%, and increased the NK cell activity of splenocytes by 51.6% compared with the control group. The complement activity of EXP was increased in accordance with an increase in concentration. The phosphatase activity of macrophages was increased by 0.7‐fold (200 µg/mL) compared with the control group. This EXP contained 58.9% carbohydrate and 17.1% protein. The major sugar of EXP was composed of mannose and glucose, while the protein mainly consisted of serine, glycine and aspartic acid. Copyright © 2008 John Wiley & Sons, Ltd.