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A ‘Yang‐Invigorating’ Chinese herbal formula protects against gentamicin‐induced nephrotoxicity in rats
Author(s) -
Poon Michel K. T.,
Chiu P. Y.,
Leung H. Y.,
Siu Ada H. L.,
Ko K. M.
Publication year - 2008
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2257
Subject(s) - nephrotoxicity , antioxidant , gentamicin , glutathione peroxidase , pharmacology , glutathione , superoxide dismutase , chemistry , medicine , kidney , biochemistry , antibiotics , endocrinology , enzyme
The effects of VI‐28 (a Yang ‐invigorating Chinese herbal formula) treatment on the renal mitochondrial antioxidant system and susceptibility to gentamicin‐induced nephrotoxicity were investigated in rats. VI‐28 treatment (80 or 240 mg/kg/day × 12) enhanced the renal mitochondrial antioxidant system, as indicated by dose‐dependent increases in the level/activities of reduced glutathione, Mn‐superoxide dismutase, Se‐glutathione peroxidase and glutathione S‐transferases. VI‐28 treatment protected against nephrotoxicity induced by gentamicin administration (100 mg/kg/day × 8) and the nephroprotection was associated with an enhancement in the renal mitochondrial antioxidant system. In conclusion, VI‐28 treatment enhanced the renal mitochondrial antioxidant system, thereby protecting against gentamicin nephrotoxicity. Copyright © 2007 John Wiley & Sons, Ltd.