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Antiproliferative properties of polyketides isolated from Virola sebifera leaves
Author(s) -
Denny Carina,
Zacharias Marcela Engelbrecht,
Ruiz Ana Lúcia Tasca Gois,
Amaral Maria do Carmo E. do,
Bittrich Volker,
Kohn Luciana Konecny,
Sousa Ilza Maria de Oliveira,
Rodrigues Rodney Alexandre Ferreira,
Carvalho João Ernesto de,
Foglio Mary Ann
Publication year - 2008
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2251
Subject(s) - fractionation , stereochemistry , chemistry , column chromatography , in vitro , cell culture , biology , biochemistry , chromatography , genetics
An activity‐guided fractionation of Virola sebifera Aubl. methylene chloride‐soluble fraction provided novel 3,5‐dihydro‐2‐(1′‐oxo‐3′‐hexadecenyl)‐2‐cyclohexen‐1‐one (3), two known lignans (1, 2) and dehydro hexadecanoyl resorcinol (4). Isolation and purification were conducted with the application of column chromatography and structures were assigned by spetral analysis (1D and 2D NMR, HREIMS). Compounds 1–4 were evaluated for cytotoxic activities against human tumour cell lines UACC62 (melanoma), MCF‐7 (breast), NCI 460 (lung, non‐small cells), OVCAR03 (ovarian), PC‐03 (prostate), HT‐29 (colon), 786‐0 (renal) and NCI‐ADR (breast expressing phenotype multiple drugs resistance) in vitro . The new polyketide (3) showed selectivity against human OVCAR03 and NCI‐ADR cell lines, ranging from 2 to 4 µg/mL. Copyright © 2007 John Wiley & Sons, Ltd.